钙调节甲状旁腺激素肽酶
Calcium-regulated parathyroid hormone peptidase.
作者信息
Fischer J A, Oldham S B, Sizemore G W, Arnaud C D
出版信息
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2341-5. doi: 10.1073/pnas.69.8.2341.
Abstract
An enzymatic activity that catalyzes the conversion of glandular parathyroid hormone to a smaller-molecular-weight, biologically and immunologically active form of this hormone has been extracted from normal parathyroid and other porcine tissues. The product of the conversion has the immunologic characteristics of the hormone that occurs in peripheral serum and in tissue culture medium from parathyroid explants. The enzyme is activated by chelating agents and is inhibited by high calcium concentrations, suggesting that this enzyme may be important in the regulation of secretion or metabolism of the hormone.
摘要
一种催化腺甲状旁腺激素转化为分子量较小、具有生物学活性和免疫活性形式的该激素的酶活性已从正常甲状旁腺和其他猪组织中提取出来。转化产物具有外周血清和甲状旁腺外植体组织培养基中存在的激素的免疫特性。该酶被螯合剂激活，被高钙浓度抑制，这表明该酶可能在激素的分泌或代谢调节中起重要作用。
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Proc Natl Acad Sci U S A. 1972 Aug;69(8):2341-5. doi: 10.1073/pnas.69.8.2341.
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