循环甲状旁腺激素前体的证据。
Evidence for a precursor to circulating parathyroid hormone.
作者信息
Sherwood L M, Rodman J S, Lundberg W B
出版信息
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1631-8. doi: 10.1073/pnas.67.3.1631.
Abstract
Bovine parathyroid glands incubated in organ culture synthesize and secrete parathyroid hormone in response to physiologic alterations in cation concentration. Hormone synthesized in the glands is immunologically different and higher in molecular weight than that released into the culture medium or circulating in bovine blood, although it is identical to purified hormone extracted from the glands. On the basis of the physiologic responses of tissue and medium hormone to cation, the transfer of radioactive label from one moiety to another, and interconversion of the two forms by a gland homogenate, it is suggested that the parathyroid glands synthesize a precursor hormone (proparathormone) that is modified to the smaller molecule that circulates in blood.
摘要
在器官培养中孵育的牛甲状旁腺会根据阳离子浓度的生理变化合成并分泌甲状旁腺激素。腺体中合成的激素在免疫学上与释放到培养基中或在牛血液中循环的激素不同，分子量也更高，尽管它与从腺体中提取的纯化激素相同。根据组织和培养基激素对阳离子的生理反应、放射性标记从一个部分转移到另一个部分以及腺体匀浆对两种形式的相互转化，有人提出甲状旁腺合成一种前体激素（甲状旁腺素原），该前体激素会被修饰成在血液中循环的较小分子。
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本文引用的文献
1
The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.人胰岛细胞腺瘤中胰岛素及胰岛素可能前体的生物合成。
Proc Natl Acad Sci U S A. 1967 Feb;57(2):473-80. doi: 10.1073/pnas.57.2.473.
2
IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE.牛和人甲状旁腺激素的免疫测定
Proc Natl Acad Sci U S A. 1963 May;49(5):613-7. doi: 10.1073/pnas.49.5.613.
3
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
4
Regulation by calcium of parathyroid growth and secretion in vitro.体外钙对甲状旁腺生长和分泌的调节
Nature. 1963 Mar 16;197:1115-6. doi: 10.1038/1971115a0.
5
Growth of embryonic avian and mammalian tibiae on a relatively simple chemically defined medium.胚胎期禽类和哺乳动物胫骨在相对简单的化学成分明确的培养基上的生长。
Exp Cell Res. 1961 Oct;25:41-58. doi: 10.1016/0014-4827(61)90305-6.
6
In vitro studies of normal and abnormal parathyroid tissue.正常和异常甲状旁腺组织的体外研究。
Arch Intern Med. 1969 Oct;124(4):426-30.
7
A radioimmunoassay for parathyroid hormone in man.一种用于人体甲状旁腺激素的放射免疫测定法。
Proc Soc Exp Biol Med. 1968 Jun;128(2):501-4. doi: 10.3181/00379727-128-33050.
8
Immunochemical heterogeneity of parathyroid hormone in plasma.血浆中甲状旁腺激素的免疫化学异质性
J Clin Endocrinol Metab. 1968 Jul;28(7):1037-47. doi: 10.1210/jcem-28-7-1037.
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