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乙醇与高压空气对人体摇摆及心率的联合作用

Combined effects of ethanol and hyperbaric air on body sway and heart rate in man.

作者信息

Jones A W, Jennings R D, Adolfson J, Hesser C M

出版信息

Undersea Biomed Res. 1979 Mar;6(1):15-25.

PMID:462650
Abstract

Eight amateur divers took part in crossover experiments to study the combined effects of ethanol (0.72 g/kg b.wt.) and hyperbaric air (4 and 6 ATA) on heart rate and body-sway movements. Body sway with open and closed eyes was measured in lateral and sagittal directions by a statometer device. In the alcohol condition, there was an initial increase in body sway corresponding to the acute phase of ethanol intoxication. At a mean blood alcohol concentration of 0.77 mg/ml, this increase in body sway was statistically significant (P less than 0.01) compared with the alcohol-free condition. At 90 min from start of drinking, body sway scores at 1 ATA were not significantly different from alcohol-free measurements. On raising the pressure to 4 and 6 ATA, increased body sway occurred in both alcohol and alcohol-free conditions and, moreover, the rate of increase was more extreme in the alcohol condition. Significant pressure-alcohol interactions were established, suggesting a potentiating action of alcohol on the increase in body sway induced by acute exposure to high pressures of air. Heart-rate measurements with and without alcohol were not significantly different, although increases in ambient pressure caused a drop in heart rate in both conditions.

摘要

八名业余潜水员参与了交叉实验,以研究乙醇(0.72克/千克体重)和高压空气(4和6个绝对大气压)对心率和身体摇摆运动的联合影响。使用静态平衡仪装置在横向和矢状方向上测量睁眼和闭眼时的身体摇摆。在饮酒状态下,身体摇摆最初会增加,这与乙醇中毒的急性期相对应。在平均血液酒精浓度为0.77毫克/毫升时,与未饮酒状态相比,这种身体摇摆的增加具有统计学意义(P小于0.01)。在开始饮酒90分钟后,1个绝对大气压下的身体摇摆得分与未饮酒时的测量结果无显著差异。将压力提高到4和6个绝对大气压时,饮酒和未饮酒状态下身体摇摆均增加,而且在饮酒状态下增加速率更为明显。确定了显著的压力-酒精相互作用,表明酒精对急性暴露于高气压空气中所引起的身体摇摆增加具有增强作用。无论有无酒精,心率测量结果均无显著差异,尽管环境压力增加在两种状态下均导致心率下降。

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