Nauta W J
Acta Neurobiol Exp (Wars). 1972;32(2):125-40.
Recent anatomical findings in the monkey indicate that the frontal cortex receives associative afferents from the visual, auditory, and somatosemsory areas of the cortex. The inferior parietal lobule and the inferior temporal cortex are important way-stations in these cortico-cortical afferent pathways. The olfactory system represents a fourth sensorium having access to the frontal cortex, namely, by way of substantial projections from the pirifom cortex and olfactory tubercle to the medial subdivision of the thalamic mediodorsal nucleus. Additional afferents to this nucleus originate from various fore- and midbrain structures implicated in the circuitry of the limbic system; such afferents could well be ediators of information related to the organism's internal milieu. On the efferent side, the frontal cortex is associated with the inferior parietal, temporal, cinguloparahippocampal cortex, and entorhinal area; it is the only cortical region known to project directly to the hypothalamus and hypothalamus-related structures in the paramedian midbrain tegmentum. The mosaic of origin and termination of the various connections indicates that the convexity of the frontal lobe (especially its caudal half) is reciprocally associated with the parietal and temporal cortex, while the major associations with the hippocampal mechanism originate from two separate areas, viz. the caudal orbitofrontal cortex and a region dorsal to the sulcus principalis, frontal fields from which also the major fronto-hypothalamic connections arise.
最近在猴子身上的解剖学发现表明，额叶皮质接收来自视觉、听觉和躯体感觉皮质区域的联合传入纤维。顶下小叶和颞下皮质是这些皮质 - 皮质传入通路中的重要中转站。嗅觉系统是第四个与额叶皮质相连的感觉系统，即通过梨状皮质和嗅结节向丘脑背内侧核内侧亚群的大量投射实现连接。该核的其他传入纤维来自参与边缘系统回路的各种前脑和中脑结构；这些传入纤维很可能是与机体内部环境相关信息的传递者。在传出方面，额叶皮质与顶下、颞叶、扣带回 - 海马旁皮质和内嗅区相关联；它是已知唯一直接投射到下丘脑以及中脑旁正中被盖中与下丘脑相关结构的皮质区域。各种连接的起始和终止分布表明，额叶凸面（尤其是其尾侧半部）与顶叶和颞叶皮质相互关联，而与海马机制的主要联系则源自两个不同区域，即尾侧眶额皮质和中央沟背侧的一个区域，主要的额 - 下丘脑连接也起源于这两个额叶区域。
