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粪肠球菌中的叶酸代谢。

Folate metabolism in Streptococcus faecalis.

作者信息

McElwee P G, Scott J M

出版信息

Biochem J. 1972 May;127(5):901-5. doi: 10.1042/bj1270901.

Abstract

The possibility that the inability of Streptococcus faecalis to utilize 5-methyltetrahydropteroylglutamate or pteroyltriglutamate might be due to permeability was investigated. Whereas the former was taken up by S. faecalis cells growing on pteroylglutamic acid, the latter was not. No subsequent conversion of the 5-methyltetrahydropteroylglutamate took place and accumulation, which was against a considerable concentration gradient, was inhibited by fluoride. It would thus appear to be an active process.

摘要

粪链球菌无法利用5-甲基四氢蝶酰谷氨酸或蝶酰三谷氨酸可能是由于通透性问题,对此进行了研究。在蝶酰谷氨酸上生长的粪链球菌细胞能摄取前者,却不能摄取后者。5-甲基四氢蝶酰谷氨酸随后未发生转化,且其积累是逆着相当大的浓度梯度进行的,这种积累受到氟化物的抑制。因此,这似乎是一个主动过程。

相似文献

1
Folate metabolism in Streptococcus faecalis.粪肠球菌中的叶酸代谢。
Biochem J. 1972 May;127(5):901-5. doi: 10.1042/bj1270901.
6
Enzymatic hydrolysis of pteroylpolyglutamates in cabbage.卷心菜中蝶酰多谷氨酸的酶促水解
Proc Soc Exp Biol Med. 1972 Dec;141(3):1022-5. doi: 10.3181/00379727-141-36924.

本文引用的文献

1
FOLATES AND MEGALOBLASTIC ANEMIA: A REVIEW.叶酸与巨幼细胞贫血:综述
Clin Pharmacol Ther. 1965 May-Jun;6:372-92. doi: 10.1002/cpt196563372.
7
Intestinal absorption of reduced folate compounds in man.人体中还原型叶酸化合物的肠道吸收
Br J Haematol. 1970 Mar;18(3):329-39. doi: 10.1111/j.1365-2141.1970.tb01447.x.

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