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Inhibition of thymidylate synthetase by showdomycin and its 5'-phosphate.

作者信息

Kalman T I

出版信息

Biochem Biophys Res Commun. 1972 Nov 15;49(4):1007-13. doi: 10.1016/0006-291x(72)90312-9.

DOI:10.1016/0006-291x(72)90312-9
PMID:4629808
Abstract
摘要

相似文献

1
Inhibition of thymidylate synthetase by showdomycin and its 5'-phosphate.放线菌素及其5'-磷酸对胸苷酸合成酶的抑制作用。
Biochem Biophys Res Commun. 1972 Nov 15;49(4):1007-13. doi: 10.1016/0006-291x(72)90312-9.
2
Affinity chromatography of thymidylate synthetases using 5-fluoro-2'-deoxyuridine 5'-phosphate derivatives of sepharose.使用琼脂糖的5-氟-2'-脱氧尿苷5'-磷酸衍生物对胸苷酸合成酶进行亲和层析。
Adv Exp Med Biol. 1974;42(0):135-46. doi: 10.1007/978-1-4684-6982-0_10.
3
Thymidylate synthetase catalyzed dehalogenation of 5-bromo-and 5-iodo-2'-deoxyuridylate.
Biochem Biophys Res Commun. 1975 Nov 17;67(2):818-23. doi: 10.1016/0006-291x(75)90886-4.
4
Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate.来自胸苷酸合成酶的活性位点肽的纯化及氨基酸分析,该肽含有共价结合的5-氟-2'-脱氧尿苷酸和亚甲基四氢叶酸。
Biochem Biophys Res Commun. 1974 Apr 8;57(3):689-95. doi: 10.1016/0006-291x(74)90601-9.
5
Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides.
Biochemistry. 1974 Feb 26;13(5):926-33. doi: 10.1021/bi00702a016.
6
Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. Purification by affinity chromatography.来自抗氨甲蝶呤干酪乳杆菌的胸苷酸合成酶。通过亲和色谱法进行纯化。
Biochemistry. 1974 May 7;13(10):2044-50. doi: 10.1021/bi00707a007.
7
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.胸苷酸合成酶与5-氟脱氧尿苷酸的相互作用机制。
Biochemistry. 1974 Jan 29;13(3):471-81. doi: 10.1021/bi00700a012.
8
5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.
J Med Chem. 1979 Sep;22(9):1137-9. doi: 10.1021/jm00195a028.
9
Fluorescent inhibitors of thymidylate synthetase.胸苷酸合成酶的荧光抑制剂。
J Pharm Sci. 1977 Mar;66(3):434-6. doi: 10.1002/jps.2600660334.
10
The inactivation of thymidylate synthase by periodate.
J Inorg Biochem. 1984 Dec;22(4):259-70. doi: 10.1016/0162-0134(84)85011-4.

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1
Reinvestigation of the -Glycoside Synthase in Alnumycin Biosynthesis Reveals a Conserved Mechanism of C-C Bond Formation.对铝霉素生物合成中糖苷合酶的重新研究揭示了碳-碳键形成的保守机制。
J Am Chem Soc. 2025 Jun 18;147(24):20571-20581. doi: 10.1021/jacs.5c03469. Epub 2025 Jun 4.
2
R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA.
Mol Gen Genet. 1974;133(2):163-74. doi: 10.1007/BF00264837.
3
Bacteriophage T4 baseplate components. III. Location and properties of the bacteriophage structural thymidylate synthetase.噬菌体T4基板组件。III. 噬菌体结构胸苷酸合成酶的定位与特性
J Virol. 1975 Dec;16(6):1409-19. doi: 10.1128/JVI.16.6.1409-1419.1975.
4
Amino acid sequence at the FdUMP binding site of thymidylate synthetase.胸苷酸合成酶的FdUMP结合位点处的氨基酸序列。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1848-52. doi: 10.1073/pnas.73.6.1848.