5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.
作者信息
Chang C T, Edwards M W, Torrence P F, Mertes M P
出版信息
J Med Chem. 1979 Sep;22(9):1137-9. doi: 10.1021/jm00195a028.
PMID:114660
Abstract
The 5'-phosphate (1) of the antiviral nucleoside 5-cyano-2'-deoxyuridine was synthesized and evaluated for inhibition of thymidylate synthetase purified from methotrexate-resistant Lactobacillus casei. Compound 1 was a potent competitive inhibitor with a K1 of 0.55 microns. Irreversible enzyme inhibition by this compound could not be detected.
摘要
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