疫苗对铜绿假单胞菌定植烧伤的早期保护作用。
Early protection by vaccines against Pseudomonas aeruginosa colonizing burns.
作者信息
Jones R J, Lowbury E J
出版信息
Br J Exp Pathol. 1972 Dec;53(6):659-64.
Abstract
Burned mice were successfully protected by a single injection of P14 vaccine against the homologous strain of Pseudomonas when a suspension of the bacteria was inoculated over the burned area 2 or 3 days later. Unvaccinated mice challenged in this way died with septicaemia when their burns were kept moist by application of an inert cream and dressings; if the burns were exposed, the mice died when challenged after 2 hours or 24 hours, but often survived if the challenge was delayed for 48 or 72 hours.
摘要
当在烧伤2或3天后将细菌悬液接种于烧伤部位时，单次注射P14疫苗可成功保护烧伤小鼠免受同源假单胞菌菌株的侵害。当通过涂抹惰性乳膏和敷料使烧伤保持湿润时，以这种方式受到攻击的未接种疫苗的小鼠死于败血症；如果烧伤部位暴露，小鼠在2小时或24小时后受到攻击时死亡，但如果攻击延迟48或72小时，它们通常会存活下来。
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