Raettig H, Schimmrich B
Wien Klin Wochenschr. 1979 Jun 22;91(13):445-8.
Mice in ether narcosis were immunized 10 times by means of an inhalation spray with Begrivacs S (Behring-Werke) and then infected nasally with the virulent A/PR8 virus 7 to 12 days after the last immunization. A significant protection was achieved as gauged from the mortality rate. Furthermore, mice were nasally immunized with the polyvalent bacterial lysate vaccine IRS 19 (Sarbach, Chatillon) and subsequently infected nasally with the virulent influenza virus. A significant degree of non-specific protection also developed under these conditions, but was less effective than that after specific immunization. The best protective effect can be gained by applying both vaccines (Begrivac S and IRS 19) in combination. In this case, the mortality rate of the test animals decreases from 68% in the control to 31% in the animals receiving combined vaccination.
将处于乙醚麻醉状态的小鼠通过吸入喷雾方式用贝氏疫苗S（贝林公司）免疫10次，然后在最后一次免疫后7至12天经鼻腔感染强毒株A/PR8病毒。从死亡率来看，获得了显著的保护效果。此外，用多价细菌裂解物疫苗IRS 19（萨尔巴赫公司，沙蒂永）对小鼠进行鼻腔免疫，随后经鼻腔感染强毒流感病毒。在这些条件下也产生了显著程度的非特异性保护，但效果不如特异性免疫后好。同时应用两种疫苗（贝氏疫苗S和IRS 19）可获得最佳保护效果。在这种情况下，试验动物的死亡率从对照组的68%降至联合接种疫苗动物的31%。
