Zhu Qiang, Chang Haiyan, Chen Yan, Fang Fang, Xue Changyong, Zhang Fenghua, Qiu Meizhen, Wang Hanzhong, Wang Bin, Chen Ze
College of Life Science, Hunan Normal University, Changsha, 410081 Hunan, People's Republic of China.
Biochem Biophys Res Commun. 2005 Apr 1;329(1):87-94. doi: 10.1016/j.bbrc.2005.01.109.
Influenza virus infection frequently causes complications and some excess mortality in the patients with diabetes. Vaccination is an effective measure to prevent influenza virus infection. In this paper, antibody response and protection against influenza virus infection induced by vaccination were studied in mouse model of diabetes. Healthy and diabetic BALB/c mice were immunized once or twice with inactivated influenza virus vaccine at various dosages. Four weeks after the first immunization or 1 week after the second immunization, the mice were challenged with influenza virus at a lethal dose. The result showed that the antibody responses in diabetic mice were inhibited. Immunization once with high dose or twice with low dose of vaccine provided full protection against lethal influenza virus challenge in diabetic mice, however, in healthy mice, immunization only once with low dose provided a full protection.
流感病毒感染经常会在糖尿病患者中引发并发症以及一些额外的死亡情况。接种疫苗是预防流感病毒感染的有效措施。在本文中，在糖尿病小鼠模型中研究了接种疫苗诱导的抗体反应及对流感病毒感染的保护作用。健康和糖尿病BALB/c小鼠用不同剂量的灭活流感病毒疫苗免疫一次或两次。首次免疫四周后或第二次免疫一周后，用致死剂量的流感病毒攻击小鼠。结果显示糖尿病小鼠的抗体反应受到抑制。高剂量免疫一次或低剂量免疫两次可为糖尿病小鼠提供针对致死性流感病毒攻击的完全保护，然而，在健康小鼠中，仅低剂量免疫一次就可提供完全保护。
Zotero 插件