甲状旁腺激素的放射免疫测定：高钙血症性甲状旁腺功能亢进症的区域定位（作者译）

[Radioimmunological determination of parathyroid hormone: regional localization in hypercalcaemic hyperparathyroidism (author's transl)].

作者信息

Dudczak R, Waldhäusl W, Wolner E, Czembirek H

出版信息

Wien Klin Wochenschr. 1979 Jun 22;91(13):464-9.

Abstract

Angiographic or scintigraphic localization of parathyroid adenomas is successful in only a small number of patients with hypercalcaemic hyperparathyroidism. This report is concerned with the preoperative localization of parathyroid adenomas by regional catheterization of the thyroid veins in patients with hypercalcaemic hyperparathyroidism (n = 7). PTH was determined radioimmunologically, using an antiserum specific for PTH1-84 and the carboxyl-terminal fragment of the hormone. Determination of regional differences in the plasma concentration of PTH permitted the preoperative localization of PTH secreting adenomas. The preoperative localization of parathyroid adenomas was confirmed in each instance by surgery. Thus, the regional determination of plasma PTH represents a tool to improve the preoperative localization of parathyroid adenomas in patients with hypercalcaemic hyperparathyroidism and, hence, to reduce the risk of an unsuccessful operation.

摘要

甲状旁腺腺瘤的血管造影或闪烁显像定位仅在少数高钙血症性甲状旁腺功能亢进患者中成功。本报告关注的是通过对高钙血症性甲状旁腺功能亢进患者（n = 7）的甲状腺静脉进行区域导管插入术来对甲状旁腺腺瘤进行术前定位。使用针对PTH1 - 84和该激素羧基末端片段的抗血清，通过放射免疫法测定甲状旁腺激素（PTH）。测定血浆PTH浓度的区域差异可实现分泌PTH腺瘤的术前定位。每次甲状旁腺腺瘤的术前定位均通过手术得到证实。因此，血浆PTH的区域测定是一种改善高钙血症性甲状旁腺功能亢进患者甲状旁腺腺瘤术前定位的工具，从而降低手术失败的风险。

相似文献

1

[Radioimmunological determination of parathyroid hormone: regional localization in hypercalcaemic hyperparathyroidism (author's transl)].甲状旁腺激素的放射免疫测定：高钙血症性甲状旁腺功能亢进症的区域定位（作者译）

Wien Klin Wochenschr. 1979 Jun 22;91(13):464-9.

2

[PTH radioimmunoassay on selective venous samplings as a method of localization of parathyroid adenomas in primary hyperparathyroidism (author's transl)].[选择性静脉采血甲状旁腺激素放射免疫测定作为原发性甲状旁腺功能亢进症甲状旁腺腺瘤定位方法（作者译）]

Urologe A. 1978 Jan;17(1):23-8.

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[Parathormone determination with synthetic human parathormone 1-34 (PTH) (author's transl)].用合成人甲状旁腺激素1-34（PTH）测定甲状旁腺激素（作者译）

MMW Munch Med Wochenschr. 1975 Jun 6;117(23):1005-8.

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[Preoperative localization diagnosis of parathyroid adenomas in 72 cases of primary hyperparathyroidism by selective catheterization of neck veins and parathyroid hormone determination].[72例原发性甲状旁腺功能亢进症患者甲状旁腺腺瘤的术前定位诊断：经颈静脉选择性插管及甲状旁腺激素测定]

Schweiz Med Wochenschr. 1983 Apr 30;113(17):636-40.

5

[Preoperative localization of parathyroid adenomas by means of the determination of parathyroid hormone and selective venous catheterization].[通过甲状旁腺激素测定和选择性静脉插管对甲状旁腺腺瘤进行术前定位]

Minerva Chir. 1977 Apr 30;32(8):491-8.

6

[Preoperative location of parathyroid adenomas using supraselective parathyroid hormone determination in the blood of the cervical veins].[通过测定颈静脉血中超选择性甲状旁腺激素来进行甲状旁腺腺瘤的术前定位]

Chirurg. 1978 Dec;49(12):745-51.

7

[Selective parathormone determination for localizing parathyroid tumors].[用于定位甲状旁腺肿瘤的选择性甲状旁腺激素测定]

Langenbecks Arch Chir. 1975;Suppl:457-60.

8

Pre-operative localization of parathyroid tissue by selective neck vein catheterization and radioimmunoassay of parathyroid hormone.通过选择性颈静脉插管和甲状旁腺激素放射免疫测定对甲状旁腺组织进行术前定位。

Acta Chir Scand. 1975;141(1):31-9.

9

[A symptomatic parathyroid adenoma. Value of parathyroid hormone determination through selective catheterization of the thyroid veins].[无症状性甲状旁腺腺瘤。通过甲状腺静脉选择性插管测定甲状旁腺激素的价值]

Arch Fr Pediatr. 1977 Feb;34(2):171-8.

10

[Letter: Persistent primary hyperparathyroidism after parathyroidectomy. Attempt to localize the remaining adenoma by venous catheterization and radioimmunologic dosage of parathyroid hormone (PTH)].[信件：甲状旁腺切除术后持续性原发性甲状旁腺功能亢进。尝试通过静脉插管和甲状旁腺激素（PTH）放射免疫测定法定位残留腺瘤]

Nouv Presse Med. 1974;3(41-43):2580.

引用本文的文献

1

Acute effect of cimetidine and pirenzepine on plasma parathyroid hormone and calcitonin in haemodialyzed patients.西咪替丁和哌仑西平对血液透析患者血浆甲状旁腺激素和降钙素的急性影响。

Eur J Clin Pharmacol. 1983;25(5):609-13. doi: 10.1007/BF00542347.

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