Zazgornik J, Dudczak R, Fuhrmann M, Marosi L, Minar E, Balcke P
Eur J Clin Pharmacol. 1983;25(5):609-13. doi: 10.1007/BF00542347.
The acute effects of intravenous injection of cimetidine and pirenzepine on plasma iPTH and CT were studied in seven patients on chronic haemodialysis and seven healthy controls. As expected, the resting iPTH and CT levels were significantly higher in patients on RDT than in the healthy subjects. Both drugs decreased to a similar extent the increased plasma iPTH in the patients, but neither was able entirely to normalize the elevated level. The CT concentration in the patients on haemodialysis was significantly decreased by cimetidine but was only moderately reduced by pirenzepine. As neither drug was able to normalize the elevated PTH level in patients on chronic dialysis, it can be assumed that neither used alone would improve signs and symptoms of secondary hyperparathyroidism.
对7例慢性血液透析患者和7名健康对照者静脉注射西咪替丁和哌仑西平后，研究了其对血浆免疫反应性甲状旁腺激素（iPTH）和降钙素（CT）的急性影响。正如预期的那样，接受规律透析治疗（RDT）的患者静息时的iPTH和CT水平显著高于健康受试者。两种药物都能使患者升高的血浆iPTH降低至相似程度，但都不能完全使升高的水平恢复正常。西咪替丁显著降低了血液透析患者的CT浓度，而哌仑西平仅使其适度降低。由于两种药物都不能使慢性透析患者升高的甲状旁腺激素水平恢复正常，因此可以认为单独使用其中任何一种都不会改善继发性甲状旁腺功能亢进的体征和症状。
