1950 - 1971年囊性纤维化患者呼吸道的细菌菌群
Bacterial flora of respiratory tract in patients with cystic fibrosis, 1950-71.
作者信息
Mearns M B, Hunt G H, Rushworth R
出版信息
Arch Dis Child. 1972 Dec;47(256):902-7. doi: 10.1136/adc.47.256.902.
The bacterial flora of the respiratory tract of patients with cystic fibrosis was observed from 1950 onwards. Serum precipitins against and were determined in the serum of 102 patients. A trend of change in the bacterial flora was noted; the isolation rate of fell, whether related to age or severity of disease, while after 1964 there was an increased isolation rate of in the most severely affected patients. Bacterial precipitins were found in 55 of 102 patients. Generally the presence of these correlated with the radiological changes. Pseudomonas precipitins were found chiefly in patients with generalized changes, while precipitins against staphylococcus and haemophilus occurred more in patients who had either no radiological change or less severe changes. These findings have relevance to the management of patients with cystic fibrosis. It is suggested that factors other than bacterial infection may initiate the lung changes in children with cystic fibrosis.
自1950年起，对囊性纤维化患者呼吸道的细菌菌群进行了观察。测定了102例患者血清中针对[具体细菌名称未给出]和[具体细菌名称未给出]的沉淀素。注意到细菌菌群的变化趋势；无论与年龄或疾病严重程度相关，[具体细菌名称未给出]的分离率均下降，而1964年后，在受影响最严重的患者中，[具体细菌名称未给出]的分离率有所上升。102例患者中有55例发现细菌沉淀素。一般来说，这些沉淀素的存在与放射学变化相关。铜绿假单胞菌沉淀素主要在有广泛性变化的患者中发现，而针对葡萄球菌和嗜血杆菌的沉淀素在无放射学变化或变化较轻的患者中出现得更多。这些发现与囊性纤维化患者的管理相关。有人提出，除细菌感染外的其他因素可能引发囊性纤维化儿童的肺部变化。
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