囊性纤维化中的细菌感染
Bacterial infection in cystic fibrosis.
作者信息
May J R, Herrick N C, Thompson D
出版信息
Arch Dis Child. 1972 Dec;47(256):908-13. doi: 10.1136/adc.47.256.908.
Tests for precipitins against and were carried out on the serum of 195 patients with cystic fibrosis, whose ages ranged from 3 weeks to 31 years. Sputum was obtained for culture from 96 patients over 5 years old. Precipitins against were more common than those against any other organism, including in the 0- to 5- and 6- to 10- year-old groups, while mucoid was the commonest pathogen isolated from the sputum of the 6- to 10-year-old children. These findings suggest that is the commonest bronchial pathogen in the younger patients and seem to conflict with the belief that is always the initial pathogen in cystic fibrosis. Indeed, in 2 patients was proved to be the initial pathogen, and it is probable that patients with cystic fibrosis are susceptible from birth to bronchial infection by any pathogen with which they come in contact. The prevalence of pseudomonas infection, in contrast to that for staphylococcal or haemophilus infections, fell strikingly in the oldest patients, and this may reflect the failure of many patients with pseudomonas infections to survive into adult life.
对195例年龄在3周至31岁之间的囊性纤维化患者的血清进行了针对[具体细菌名称1]和[具体细菌名称2]的沉淀素检测。从96例5岁以上的患者获取痰液进行培养。在0至5岁和6至10岁年龄组中，针对[具体细菌名称1]的沉淀素比针对任何其他微生物（包括[具体细菌名称2]）的沉淀素更为常见，而黏液样[具体细菌名称2]是从6至10岁儿童痰液中分离出的最常见病原体。这些发现表明，[具体细菌名称1]是较年轻患者中最常见的支气管病原体，这似乎与囊性纤维化中[具体细菌名称2]总是初始病原体的观点相矛盾。事实上，在2例患者中，[具体细菌名称2]被证明是初始病原体，并且囊性纤维化患者很可能从出生起就易受与其接触的任何病原体引起的支气管感染。与葡萄球菌或嗜血杆菌感染相比，铜绿假单胞菌感染的患病率在年龄最大的患者中显著下降，这可能反映出许多铜绿假单胞菌感染患者未能存活至成年。
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