Heilpern S, Rebuck A S
Thorax. 1972 Nov;27(6):726-8. doi: 10.1136/thx.27.6.726.
The protein content in the sputum of nine patients with asthma was compared with that in 11 non-asthmatic patients by a method of gel electrophoresis. It was found that the albumin content was significantly higher in the sputum of the asthmatics than of the non-asthmatics (P<0·01). A further 11 asthmatic patients who were taking disodium cromoglycate (Intal) as part of their treatment had sputum albumin levels indistinguishable from the non-asthmatics. When patients with asthma were then studied serially, before and after disodium cromoglycate therapy, the albumin content returned to non-asthmatic levels within two days of starting treatment. It is suggested that disodium cromoglycate has a previously unrecognized action in altering sputum proteins.
采用凝胶电泳法对9例哮喘患者痰液中的蛋白质含量与11例非哮喘患者痰液中的蛋白质含量进行了比较。结果发现，哮喘患者痰液中的白蛋白含量显著高于非哮喘患者（P<0·01）。另有11例正在接受色甘酸钠（咽泰）治疗的哮喘患者，其痰液白蛋白水平与非哮喘患者无异。随后对哮喘患者在色甘酸钠治疗前后进行了连续研究，发现治疗开始后两天内白蛋白含量恢复到非哮喘患者的水平。提示色甘酸钠在改变痰液蛋白质方面具有此前未被认识到的作用。
