Brogan T D, Ryley H C, Allen L, Hutt H
Thorax. 1971 Jul;26(4):418-23. doi: 10.1136/thx.26.4.418.
Sixty-four patients with various chest diseases were divided on clinical grounds into those suffering from asthma, chronic bronchitis, and chronic bronchitis with heart failure and those with damage to the lung parenchyma. A 24-hour specimen of sputum was collected from each patient and the electrolyte, protein, and carbohydrate composition was determined on the sol phase which was separated by ultracentrifugation. High variance was encountered in all the results and no difference in average pH and ionic concentration was found between the four groups. The average sol phase carbohydrate concentration and the average proportion of albumin in the sol phase high-molecular-weight substances differed between the groups and appeared to be related to the diagnosis of asthma and bronchitis. We think that the proportion of albumin in sputum sol phase high-molecular-weight substances might hold promise as a criterion for distinguishing between asthma and chronic bronchitis.
64例患有各种胸部疾病的患者根据临床情况被分为患有哮喘、慢性支气管炎、伴有心力衰竭的慢性支气管炎患者以及肺实质受损的患者。从每位患者收集24小时痰液标本，并对通过超速离心分离出的溶胶相中的电解质、蛋白质和碳水化合物成分进行测定。所有结果均存在高变异性，四组之间的平均pH值和离子浓度未发现差异。各组之间溶胶相碳水化合物平均浓度以及溶胶相高分子量物质中白蛋白的平均比例有所不同，并且似乎与哮喘和支气管炎的诊断有关。我们认为，痰液溶胶相高分子量物质中白蛋白的比例可能有望作为区分哮喘和慢性支气管炎的标准。
