与黑腹果蝇肿瘤头部异常相关的母体效应基因的剂量
Dosage of the maternal effect gene associated with the tumorous-head abnormality in Drosophila melanogaster.
作者信息
Siervogel R M
出版信息
Genetics. 1972 Oct;72(2):377-80. doi: 10.1093/genetics/72.2.377.
The penetrance of tuh-3 observed in the progeny of triploids with two doses of tuh-1 was not statistically different from that occurring in the progeny of their diploid sisters with two doses. A higher penetrance was observed in the progeny of triploids with three doses of tuh-1 than in the progeny of their diploid sisters with two doses. These observations suggest that the maternal effect responsible for increasing the penetrance of tuh-3, the gene causing the tumorous-head abnormality, is caused by a specific gene product of tuh-1, the maternal-effect allele. In addition there is probably a maternal-effect threshold, lying between amounts produced by one and two doses of tuh-1, below which no increased penetrance of tuh-3 is observed.
在具有两剂量tuh-1的三倍体后代中观察到的tuh-3外显率与具有两剂量的其二倍体姐妹后代中出现的外显率在统计学上没有差异。在具有三剂量tuh-1的三倍体后代中观察到的外显率高于具有两剂量的其二倍体姐妹后代。这些观察结果表明，导致肿瘤头异常的基因tuh-3外显率增加的母体效应是由母体效应等位基因tuh-1的特定基因产物引起的。此外，可能存在一个母体效应阈值，介于一剂量和两剂量tuh-1产生的量之间，低于该阈值则未观察到tuh-3外显率增加。
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