Kuhn D T, Woods D F, Andrew D J
Genetics. 1981 Sep;99(1):99-107. doi: 10.1093/genetics/99.1.99.
In the presence of the naturally occurring maternal-effect alleles tuh-1h or tuh-1g, the tuh-3 mutant gene can cause the tumorous-head trait or the sac-testis trait. The tuh-3 gene functions as a semidominant in the presence of the tuh-1h maternal effect. Eye-antennal structures are replaced by posterior abdominal tergites and genital structures. If tuh-1h is replaced by its naturally occurring allele tuh-1g, tuh-3 functions as a recessive hypomorph and the defect switches from anterior to posterior structures, with a male genital-disc defect appearing with variable penetrance. Function and regulation of tuh-3+ may better be understood in light of the cytological localization of tuh-3 either adjacent to or as part of the bithorax complex. The tuh-3+ gene product appears to be essential for normal development, at least in the posterior end of the embryo.
在天然存在的母体效应等位基因tuh-1h或tuh-1g存在的情况下，tuh-3突变基因可导致头部肿瘤性状或囊状睾丸性状。在tuh-1h母体效应存在时，tuh-3基因表现为半显性。眼触角结构被腹部后胸节和生殖结构所取代。如果tuh-1h被其天然存在的等位基因tuh-1g取代，tuh-3则表现为隐性亚效等位基因，缺陷从前部结构转变为后部结构，雄性生殖盘缺陷以可变的外显率出现。鉴于tuh-3在双胸复合体附近或作为其一部分的细胞学定位，可能会更好地理解tuh-3+的功能和调控。tuh-3+基因产物似乎对正常发育至关重要，至少在胚胎的后端是这样。
