黑腹果蝇中黄蝶呤的终末合成。3. 苯并恶嗪酮合成酶的突变多效性及色素颗粒关联
Terminal synthesis of xanthommatin in Drosophila melanogaster. 3. Mutational pleiotropy and pigment granule association of phenoxazinone synthetase.
作者信息
Phillips J P, Forrest H S, Kulkarni A D
出版信息
Genetics. 1973 Jan;73(1):45-56. doi: 10.1093/genetics/73.1.45.
Abstract
Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), including two which effect other enzymes in the xanthommatin pathway (v, cn), have low levels of phenoxazinone synthetase activity and disrupt the normal association of the enzyme with the pigment granule. A model is proposed depicting several structural and enzymatic interrelationships involved in the developmental control of xanthommatin synthesis in Drosophila.
摘要
吩恶嗪酮合成酶催化3-羟基犬尿氨酸缩合形成果蝇的棕色眼色素黄蝶呤，已证明它与一种类似于细胞学定义的I型色素颗粒的颗粒相关联。几个经典的眼色突变体（v、cn、st、ltd、cd、w），包括两个影响黄蝶呤合成途径中其他酶的突变体（v、cn），其吩恶嗪酮合成酶活性水平较低，并破坏了该酶与色素颗粒的正常关联。本文提出了一个模型，描述了果蝇黄蝶呤合成发育控制中涉及的几种结构和酶促相互关系。
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The development of pigment granules in the eyes of wild type and mutant Drosophila melanogaster.野生型和突变型黑腹果蝇眼睛中色素颗粒的发育。
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