Yamamoto M, Howells A J, Ryall R L
Biochem Genet. 1976 Dec;14(11-12):1077-90. doi: 10.1007/BF00485139.
Particulate fractions from the heads of Drosophila melanogaster catalyze the conversion of o-aminophenols to phenoxazinones. This particulate enzyme is stimulated by Mn2+. It has a number of features which distinguish it clearly from the Mn2+-dependent activity found in the soluble fraction. The particulate enzyme has a characteristic developmental pattern, showing a marked increase in activity at about the time of onset of xanthommatin synthesis. In addition, it is much reduced in activity in a number of xanthommatin-deficient mutants (v, cn, st, cd, and w). We believe that the head particulate enzyme is involved in xanthommatin biosynthesis and that the developmental onset of synthesis of this pigment is brought about by the synthesis or activation of this enzyme.
黑腹果蝇头部的颗粒组分可催化邻氨基酚转化为吩恶嗪酮。这种颗粒酶受 Mn2+ 刺激。它具有许多特征，使其与可溶性组分中发现的 Mn2+ 依赖性活性明显区分开来。颗粒酶具有独特的发育模式，在大约黄蝶呤合成开始时活性显著增加。此外，在一些缺乏黄蝶呤的突变体（v、cn、st、cd 和 w）中，其活性大大降低。我们认为头部颗粒酶参与了黄蝶呤的生物合成，并且这种色素合成的发育起始是由该酶的合成或激活引起的。
