在移植了同种异体胎儿肝细胞的W系贫血小鼠中存在供体类型的免疫球蛋白。
The presence of donor-type immunoglobulins in anaemic mice of the W-series transplanted with allogeneic foetal liver cells.
作者信息
Seller M J
出版信息
Immunology. 1973 Feb;24(2):249-52.
Abstract
WW mice have a genetically determined macrocytic anaemia. They may be cured by the injection of haemopoietic cells derived from foetal liver from haematologically normal mice, owing to the induction of bone marrow chimaerism. Using foetal liver cells from mice that produce immunoglobulins of a different allotype from the anaemic recipients, it is shown that, after a period of time, all cured mice produce immunoglobulins of both the donor and recipient allotypes.
摘要
WW小鼠患有由基因决定的大细胞性贫血。由于骨髓嵌合体的诱导，通过注射来自血液学正常小鼠胎儿肝脏的造血细胞，它们可能被治愈。使用来自产生与贫血受体不同同种异型免疫球蛋白的小鼠的胎儿肝细胞，结果显示，一段时间后，所有治愈的小鼠都会产生供体和受体同种异型的免疫球蛋白。
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