用抗淋巴细胞血清和同种异体造血细胞治疗的W系成年贫血小鼠中耐受性的建立。
The establishment of tolerance in adult anaemic mice of the W-series treated with anti-lymphocytic serum and allogeneic haemopoietic cells.
作者信息
Seller M J
出版信息
Clin Exp Immunol. 1970 May;6(5):639-43.
The genetically determined macrocytic anaemia of adult WW mice was cured by treatment with allogeneic (CBA) haemopoietic cells following 7 days immunosuppression with antilymphocytic serum (ALS). The immunological status of these mice was studied by following the fate of two skin grafts—one derived from the same allogeneic donor as the haemopoietic cells (CBA), and the other (A strain) completely unrelated to both the host and the haemopoietic cells. The A strain grafts were rejected while the CBA strain grafts were never rejected. It was concluded that the mice had become specifically tolerant to the CBA genotype. Following studies with chromosome markers, it was found that this tolerance was associated with a high degree of cellular chimaerism.
成年WW小鼠的遗传性大细胞贫血在接受抗淋巴细胞血清（ALS）免疫抑制7天后，通过用同种异体（CBA）造血细胞治疗得以治愈。通过追踪两个皮肤移植片的命运来研究这些小鼠的免疫状态，其中一个移植片来自与造血细胞相同的同种异体供体（CBA），另一个（A品系）与宿主和造血细胞均完全无关。A品系移植片被排斥，而CBA品系移植片从未被排斥。得出的结论是，这些小鼠已对CBA基因型产生特异性耐受。在用染色体标记进行研究后发现，这种耐受与高度的细胞嵌合现象有关。
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