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2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 1. Synthesis of 2,4-diamino-5,6,7,8-tetrahydrothianaphthena(2,3-d)pyrimidines and related compounds.

作者信息

Rosowsky A, Chaykovsky M, Chen K K, Lin M, Modest E J

出版信息

J Med Chem. 1973 Mar;16(3):185-8. doi: 10.1021/jm00261a002.

DOI:10.1021/jm00261a002
PMID:4632693
Abstract
摘要

相似文献

1
2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 1. Synthesis of 2,4-diamino-5,6,7,8-tetrahydrothianaphthena(2,3-d)pyrimidines and related compounds.
J Med Chem. 1973 Mar;16(3):185-8. doi: 10.1021/jm00261a002.
2
2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs.
J Med Chem. 1973 Mar;16(3):191-4. doi: 10.1021/jm00261a004.
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2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 2. Synthesis of 2,4-diaminopyrido(4',3':4,5)thieno(2,3-d)pyrimidines and 2,4-diamino-8H-thiopyrano(4',3':4,5)thieno(2,3-d)pyrimidines.
J Med Chem. 1973 Mar;16(3):188-91. doi: 10.1021/jm00261a003.
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Synthesis of some bis(2,4-diaminopyrimidines) and bis(2,4-diaminoquinazolines) as potential antimalarial agents.
J Med Chem. 1972 Dec;15(12):1332-3. doi: 10.1021/jm00282a034.
5
Folate antagonists. 4. Antimalarial and antimetabolite effects of 2,4-diamino-6-((benzyl)amino)pyrido(2,3-d)-pyrimidines.叶酸拮抗剂。4. 2,4-二氨基-6-（苄基）氨基吡啶并[2,3-d]嘧啶的抗疟和抗代谢作用。
J Med Chem. 1972 Aug;15(8):837-9. doi: 10.1021/jm00278a009.
6
Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects.
J Med Chem. 1972 Nov;15(11):1138-46. doi: 10.1021/jm00281a012.
7
Pyrimido(4,5-c)isoquinolines. 2. Synthesis and biological evaluation of some 6-alkyl-,6-aralkyl-, and 6-aryl-1,3-diamino-7,8,9,10-tetrahydropyrimido(4,5-c)isoquinolines as potential folate antagnoists 1.
J Med Chem. 1974 Dec;17(12):1272-6. doi: 10.1021/jm00258a008.
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Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
J Med Chem. 1974 Nov;17(11):1212-6. doi: 10.1021/jm00257a015.
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Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines.
J Med Chem. 1978 Jul;21(7):639-43. doi: 10.1021/jm00205a009.
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Pteridines. 2. New 6,7-disubstituted pteridines as potential antimalarial and antitumor agents.蝶啶。2. 新型6,7-二取代蝶啶作为潜在的抗疟和抗肿瘤药物。
J Med Chem. 1973 Aug;16(8):869-75. doi: 10.1021/jm00266a001.

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