Boris A, Hurley J F, Trmal T, Mallon J P, Matuszewski D S
Acta Endocrinol (Copenh). 1979 Jun;91(2):351-61. doi: 10.1530/acta.0.0910351.
There is much experimental evidence which indicates that calcitonin in hibits bone mineral resorption, but there are few data available in support of the proposal that calcitonin may also promote mineralization. Ethane-1-hydroxy-1,1-diphosphonate (EHDP) administered to immature rats inhibited mineralization as evidenced by widened tibial epiphyseal plates and decreased bone ash to dry weight ratios. Concurrent dosing with salmon calcitonin (SCT) prevented or reversed the EHDP-blocked mineralization in a dose dependent manner. Administration of SCT during the period after EHDP treatment significantly improved mineralization of tibial epiphyseal plates as shown by plate width narrowing and increased uptake of radioactive calcium. These results suggest that SCT increased mineralization in EHDP-treated rats, and provide supportive evidence for the proposal that calcitonin may also promote mineralization, in addition to its well known ability to inhibit bone mineral resorption.
有许多实验证据表明降钙素可抑制骨矿物质吸收，但支持降钙素也可能促进矿化这一观点的数据却很少。给未成熟大鼠服用乙烷-1-羟基-1,1-二膦酸盐（EHDP）会抑制矿化，这可通过胫骨骨骺板增宽以及骨灰与干重比降低得到证明。同时给予鲑鱼降钙素（SCT）可剂量依赖性地预防或逆转EHDP阻断的矿化。在EHDP治疗后的时期给予SCT，可显著改善胫骨骨骺板的矿化，表现为板宽度变窄以及放射性钙摄取增加。这些结果表明SCT增加了EHDP处理大鼠的矿化，并为降钙素除了其众所周知的抑制骨矿物质吸收的能力外还可能促进矿化这一观点提供了支持性证据。
