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The effect of phenylpyruvate on pyruvate metabolism in rat brain.苯丙酮酸对大鼠脑内丙酮酸代谢的影响。
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2
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9
Regulation of pyruvate metabolism via pyruvate carboxylase in rat brain mitochondria.大鼠脑线粒体中通过丙酮酸羧化酶对丙酮酸代谢的调节
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10
Inhibition by the branched-chain 2-oxo acids of the 2-oxoglutarate dehydrogenase complex in developing rat and human brain.支链2-氧代酸对发育中大鼠和人脑中2-氧代戊二酸脱氢酶复合体的抑制作用。
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate.大鼠脂肪组织中的柠檬酸裂解途径与脂肪生成：草酰乙酸的补充
J Lipid Res. 1967 Mar;8(2):73-9.
3
INFLUENCE OF PHENYLALANINE ADMINISTRATION ON THE FREE AMINO ACIDS OF BRAIN AND LIVER IN THE RAT.苯丙氨酸给药对大鼠脑和肝脏游离氨基酸的影响。
J Neurochem. 1965 Jan;12:45-50. doi: 10.1111/j.1471-4159.1965.tb10250.x.
4
PYRUVATE CARBOXYLASE. I. NATURE OF THE REACTION.丙酮酸羧化酶。一、反应性质
J Biol Chem. 1963 Aug;238:2603-8.
5
Influence of alpha-ketoacids on the respiration of brain in vitro.α-酮酸对离体脑呼吸的影响。
Proc Soc Exp Biol Med. 1963 Jul;113:660-3. doi: 10.3181/00379727-113-28456.
6
A chemical investigation of the defects of myelination in phenylketonuria.苯丙酮尿症髓鞘形成缺陷的化学研究。
J Neurol Neurosurg Psychiatry. 1962 May;25(2):143-8. doi: 10.1136/jnnp.25.2.143.
7
Inhibition of 5-hydroxytryptophan decarboxylase by phenylalanine metabolites.
Nature. 1958 Jan 18;181(4603):186-7. doi: 10.1038/181186b0.
8
On the nature of enzymatic defect in phenylpyruvic oligophrenia.
Proc Soc Exp Biol Med. 1957 Apr;94(4):634-5. doi: 10.3181/00379727-94-23034.
9
Studies on conversion of phenylalanine to tyrosine in phenylpyruvic oligophrenia.苯丙酮尿症中苯丙氨酸向酪氨酸转化的研究。
Proc Soc Exp Biol Med. 1957 Apr;94(4):632-3. doi: 10.3181/00379727-94-23033.
10
Competitive inhibition of 3, 4-dihydroxyphenylalanine (DOPA) decarboxylase in vitro.
J Biol Chem. 1955 Oct;216(2):507-29.

苯丙酮酸对大鼠脑内丙酮酸代谢的影响。

The effect of phenylpyruvate on pyruvate metabolism in rat brain.

作者信息

Patel M S

出版信息

Biochem J. 1972 Jul;128(3):677-84. doi: 10.1042/bj1280677.

DOI:10.1042/bj1280677
PMID:4634834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1173818/
Abstract
  1. The effect of phenylalanine and phenylpyruvate on the metabolism of pyruvate by isolated mitochondria from rat brain was investigated. 2. Phenylpyruvate inhibited the fixation of H(14)CO(3) (-) in the presence of pyruvate by intact rat brain mitochondria, whereas phenylalanine and other metabolites of this amino acid had no inhibitory effect on this process. 3. Pyruvate carboxylase activity in freeze-dried rat brain mitochondrial preparations was also inhibited only by phenylpyruvate, and a ;mixed type' inhibition was observed. 4. The K(m) for pyruvate of rat brain pyruvate carboxylase was about 0.2mm. 5. The concentration of phenylpyruvate required for a 50% inhibition of H(14)CO(3) (-) fixation by the intact mitochondria and of pyruvate carboxylase activity was dependent on the concentration of pyruvate used in the incubation medium. 6. The possible significance of inhibition of pyruvate carboxylase activity by phenylpyruvate in the brains of phenylketonuric patients is discussed.
摘要
  1. 研究了苯丙氨酸和苯丙酮酸对大鼠脑分离线粒体丙酮酸代谢的影响。2. 苯丙酮酸在丙酮酸存在的情况下抑制完整大鼠脑线粒体对H(14)CO(3) (-)的固定，而苯丙氨酸和该氨基酸的其他代谢产物对该过程无抑制作用。3. 冻干大鼠脑线粒体制剂中的丙酮酸羧化酶活性也仅被苯丙酮酸抑制，并观察到“混合型”抑制。4. 大鼠脑丙酮酸羧化酶对丙酮酸的K(m)约为0.2mm。5. 完整线粒体对H(14)CO(3) (-)固定和丙酮酸羧化酶活性50%抑制所需的苯丙酮酸浓度取决于孵育培养基中使用的丙酮酸浓度。6. 讨论了苯丙酮酸抑制苯丙酮尿症患者脑中丙酮酸羧化酶活性的可能意义。