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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Swierczyński J, Aleksandrowicz Z, Zydowo M

Acta Biochim Pol. 1976;23(2-3):85-92.

Phenylpyruvate inhibits pyruvate plus malate oxidation in human and rat skeletal muscle mitochondria in state 3 and in the uncoupled state, it has, however, no effect in state 4. 2. Inhibition by phenylpyruvate of pyruvate oxidation by intact uncoupled rat muscle mitochondria was competitive, with the Ki value about 0.18 mM. 3. It is suggested that the inhibition of pyruvate oxidation is due to the action of phenylpyruvate on muscle pyruvate dehydrogenase, and is the principal cause of the elevated concentration of pyruvate and lactate in blood plasma of phenylketonuric patients.

苯丙酮酸在状态3和解偶联状态下抑制人和大鼠骨骼肌线粒体中丙酮酸加苹果酸的氧化，然而，在状态4下它没有作用。2. 完整的解偶联大鼠肌肉线粒体中，苯丙酮酸对丙酮酸氧化的抑制是竞争性的，Ki值约为0.18 mM。3. 有人提出，丙酮酸氧化的抑制是由于苯丙酮酸对肌肉丙酮酸脱氢酶的作用，并且是苯丙酮尿症患者血浆中丙酮酸和乳酸浓度升高的主要原因。

Swierczyński J, Aleksandrowicz Z, Zydowo M

Acta Biochim Pol. 1976;23(2-3):85-92.

Phenylpyruvate inhibits pyruvate plus malate oxidation in human and rat skeletal muscle mitochondria in state 3 and in the uncoupled state, it has, however, no effect in state 4. 2. Inhibition by phenylpyruvate of pyruvate oxidation by intact uncoupled rat muscle mitochondria was competitive, with the Ki value about 0.18 mM. 3. It is suggested that the inhibition of pyruvate oxidation is due to the action of phenylpyruvate on muscle pyruvate dehydrogenase, and is the principal cause of the elevated concentration of pyruvate and lactate in blood plasma of phenylketonuric patients.

苯丙酮酸在状态3和解偶联状态下抑制人和大鼠骨骼肌线粒体中丙酮酸加苹果酸的氧化，然而，在状态4下它没有作用。2. 完整的解偶联大鼠肌肉线粒体中，苯丙酮酸对丙酮酸氧化的抑制是竞争性的，Ki值约为0.18 mM。3. 有人提出，丙酮酸氧化的抑制是由于苯丙酮酸对肌肉丙酮酸脱氢酶的作用，并且是苯丙酮尿症患者血浆中丙酮酸和乳酸浓度升高的主要原因。