Hoshino T, Wilson C B, Muraoka I
Acta Neuropathol. 1979 Jun 15;47(1):21-5. doi: 10.1007/BF00698268.
Twelve patients with gliomas received 3H-thymidine intraarterially in combination with an i.v. mitostatic agent (Velban: 0.1 mg/kg or 3 mg/M2 of Vincristine) prior to tumor biopsy. The labeling index (LI) of each tumor was compared with the mitotic index divided by the elapsed time from administration of the mitostatic agent to biopsy (MI/t). Most of the malignant gliomas that had an LI of 5-15%, also yielded an MI/t value of 4-5 x 10(-3), whereas tumors with an LI of less than 5% generally showed very slight (0.1 x 10(-3) mitotic accumulation. Use of a mitostatic agent is suggested to differentiate the proliferative activity of various gliomas.
12例胶质瘤患者在肿瘤活检前经动脉注射3H-胸腺嘧啶核苷，并静脉注射一种有丝分裂抑制剂（长春花碱：0.1mg/kg或3mg/M2长春新碱）。将每个肿瘤的标记指数（LI）与有丝分裂指数除以从注射有丝分裂抑制剂到活检的时间间隔（MI/t）进行比较。大多数标记指数为5%-15%的恶性胶质瘤，其MI/t值也为4-5×10(-3)，而标记指数小于5%的肿瘤通常显示出非常轻微的（0.1×10(-3)）有丝分裂积累。建议使用有丝分裂抑制剂来区分各种胶质瘤的增殖活性。
