通过环己酰亚胺在体内释放先前清除的干扰素。
In vivo release of previously cleared interferon by cycloheximide.
作者信息
Chester T J, De Clercq E, Nuwer M R, Merigan T C
出版信息
Infect Immun. 1972 Mar;5(3):383-8. doi: 10.1128/iai.5.3.383-388.1972.
The release of previously cleared interferon by cycloheximide was studied in the mouse. When cycloheximide was administered after either endogenous interferon stimulation or administration of exogenous interferon, the clearance of interferon from the blood stream was interrupted and a sharp rise in interferon titer occurred approximately 6 hr after cycloheximide administration followed by a rapid decline to low levels. This effect was observed with either interferon stimulated endogenously (by polyriboinosinic.polyribocytidylic acid), or homologous (mouse) or heterologous (rabbit) interferon administered exogenously. Serum protein concentrations also exhibited this rise and fall phenomenon after cycloheximide administration although the magnitude of the change in protein concentrations was less pronounced than that observed with interferon. Hematocrits, although elevated in mice receiving cycloheximide, did not exhibit this rise and fall phenomenon. Hence, cycloheximide administration leads to the release into the circulation of previously cleared interferon as well as other proteins.
在小鼠中研究了放线菌酮对先前已清除的干扰素的释放作用。在内源性干扰素刺激或给予外源性干扰素后再给予放线菌酮时，干扰素从血流中的清除被中断，在给予放线菌酮约6小时后干扰素滴度急剧上升，随后迅速下降至低水平。无论是内源性（通过聚肌苷酸-聚胞苷酸）刺激产生的干扰素，还是外源性给予的同源（小鼠）或异源（兔）干扰素，均观察到这种效应。给予放线菌酮后，血清蛋白浓度也呈现这种先升高后降低的现象，尽管蛋白浓度变化的幅度不如干扰素明显。接受放线菌酮的小鼠的血细胞比容虽有所升高，但未呈现这种先升高后降低的现象。因此，给予放线菌酮会导致先前已清除的干扰素以及其他蛋白质释放到循环中。
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