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昼夜皮质类固醇周期性：新生期注射皮质类固醇消除该周期性的关键时期。

Circadian corticosteroid periodicity: critical period for abolition by neonatal injection of corticosteroid.

作者信息

Krieger D T

出版信息

Science. 1972 Dec 15;178(4066):1205-7. doi: 10.1126/science.178.4066.1205.

DOI:10.1126/science.178.4066.1205
PMID:4637807
Abstract

Circadian variation of corticosteroid concentrations in rat plasma is suppressed if corticosteroids are administered between days 2 to 4 of neonatal life, but not if they are given between days 12 to 14 of neonatal life. This indicates a critical period for the effect of corticosteroid administration on the central nervous system pathways regulating such periodicity. Circadian periodicity of corticosteroids is not affected by neonatal administration of testosterone or reserpine.

摘要

如果在新生大鼠出生后第2至4天之间给予皮质类固醇，其血浆中皮质类固醇浓度的昼夜变化会受到抑制，但在出生后第12至14天之间给予则不会。这表明皮质类固醇给药对调节这种周期性的中枢神经系统通路产生影响存在关键时期。皮质类固醇的昼夜周期性不受新生期给予睾酮或利血平的影响。

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Circadian corticosteroid periodicity: critical period for abolition by neonatal injection of corticosteroid.昼夜皮质类固醇周期性：新生期注射皮质类固醇消除该周期性的关键时期。
Science. 1972 Dec 15;178(4066):1205-7. doi: 10.1126/science.178.4066.1205.
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