Garina I A, Zhukov D A, Rakitskaya V V, Shalyapina V G
Neurosci Behav Physiol. 1986 Sep-Oct;16(5):448-51. doi: 10.1007/BF01185378.
Administration of hydrocortisone to rats during the first five postnatal days leads to the blockade of the hypophyseoadrenal system and results in a decrease in the number of corticosterone receptors in the hypophysis, hypothalamus, and hippocampus. Such a decrease in the receptor binding of corticosterone in the brain structures involved in the regulation of the hypophyseoadrenal system by a feedback mechanism is due to a change in the number of true glucocorticoid receptors.
在出生后的头五天给大鼠注射氢化可的松会导致垂体肾上腺系统被阻断，并致使垂体、下丘脑和海马体中皮质酮受体数量减少。通过反馈机制参与垂体肾上腺系统调节的脑结构中，皮质酮受体结合的这种减少是由于真正糖皮质激素受体数量的变化所致。
