抗抑郁药与肝脏疾病
Antidepressants and liver disease.
作者信息
Morgan M H, Read A E
出版信息
Gut. 1972 Sep;13(9):697-701. doi: 10.1136/gut.13.9.697.
Abstract
Patients with cirrhosis were found to be extremely sensitive to tranylcypromine, and the use of this drug for the treatment of depression in such patients is contraindicated. Amitriptyline has a wider margin of safety in such patients, but caution is necessary when the higher therapeutic doses are prescribed.
摘要
肝硬化患者被发现对反苯环丙胺极为敏感，因此禁止在此类患者中使用该药物治疗抑郁症。阿米替林在此类患者中的安全性范围更广，但开具较高治疗剂量时仍需谨慎。
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