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肝硬化患者的神经胃肠病学与动力障碍

Neurogastroenterology and motility disorders in patients with cirrhosis.

作者信息

Idalsoaga Francisco, Ayares Gustavo, Blaney Hanna, Cabrera Daniel, Chahuan Javier, Monrroy Hugo, Matar Ayah, Halawi Houssam, Arrese Marco, Arab Juan Pablo, Díaz Luis Antonio

机构信息

Departamento De Gastroenterología, Escuela De Medicina, Pontificia Universidad Católica De Chile, Santiago, Chile.

Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada.

出版信息

Hepatol Commun. 2025 Jan 7;9(1). doi: 10.1097/HC9.0000000000000622. eCollection 2025 Jan 1.

Abstract

Neurogastroenterology and motility disorders are complex gastrointestinal conditions that are prevalent worldwide, particularly affecting women and younger individuals. These conditions significantly impact the quality of life of people suffering from them. There is increasing evidence linking these disorders to cirrhosis, with a higher prevalence compared to the general population. However, the link between neurogastroenterology and motility disorders and cirrhosis remains unclear due to undefined mechanisms. In addition, managing these conditions in cirrhosis is often limited by the adverse effects of drugs commonly used for these disorders, presenting a significant clinical challenge in the routine management of patients with cirrhosis. This review delves into this connection, exploring potential pathophysiological links and clinical interventions between neurogastroenterology disorders and cirrhosis.

摘要

神经胃肠病学和动力障碍是复杂的胃肠道疾病,在全球范围内普遍存在,尤其影响女性和年轻人。这些疾病严重影响患者的生活质量。越来越多的证据表明这些疾病与肝硬化有关,其患病率高于普通人群。然而,由于机制尚不明确,神经胃肠病学和动力障碍与肝硬化之间的联系仍不清楚。此外,在肝硬化患者中管理这些疾病通常受到常用于治疗这些疾病的药物的不良反应的限制,这在肝硬化患者的常规管理中带来了重大的临床挑战。本综述深入探讨了这种联系,探索神经胃肠病学疾病与肝硬化之间潜在的病理生理联系和临床干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e295/11717532/bc936ef3ed0d/hc9-9-e0622-g001.jpg

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