Brinkley J R, Dubois E L, Ryan S J
Am J Ophthalmol. 1979 Jul;88(1):1-11. doi: 10.1016/0002-9394(79)90743-8.
Seven patients with chloroquine retinopathy were examined ten years after their therapy with chloroquine or hydroxychloroquine, or both, had been discontinued and an additional five patients with chloroquine retinopathy were similarly examined from two to eight years after their therapy had been discontinued. Visual acuity, visual fields, and ophthalmoscopic examinations were compared to those performed at the time therapy was discontinued. These long-term observations confirmed the previously published observations based on short-term studies that chloroquine retinopathy tends to remain stable after therapy is discontinued, although a few patients in the early stages of retinopathy may show regression and occasionally a patient with a more advanced stage of the disease may show progression.
七名患有氯喹视网膜病变的患者在停用氯喹或羟氯喹或两者治疗十年后接受了检查，另外五名患有氯喹视网膜病变的患者在停药两至八年后也进行了类似检查。将视力、视野和检眼镜检查结果与停药时的检查结果进行了比较。这些长期观察结果证实了先前基于短期研究发表的观察结果，即氯喹视网膜病变在停药后往往保持稳定，尽管少数处于视网膜病变早期的患者可能会出现病情消退，偶尔也会有病情处于更晚期的患者出现病情进展。
