Keesey R E, Mitchel J S, Kemnitz J W
Am J Physiol. 1979 Jul;237(1):R68-73. doi: 10.1152/ajpregu.1979.237.1.R68.
Carcass analyses were performed on 160 male rats maintaining reduced, normal, or elevated levels of body weight following lateral hypothalamic (LH), sham (control), or ventromedial hypothalamic (VMH) lesions, respectively. Extracted body lipid (ranging from 26 to 738% of the control mean) correlated highly (r = +0.95) with the level of maintained body weight (which ranged from 67 to 191% of control). Neither the nonfat solids (which ranged from 60 to 123% of control) contributed significantly to the variance in body weight (r = +0.01 and +0.06, respectively). Fat thus accounted for approximately 90% of the overall variance in body weight among LH, control, and VMH animals. Consideration of only the LH data, however, revealed a breakdown of this close covariance of body fat and weight. Fat mass correlated significantly with body weight in LH rats maintaining weight 0-12% below normal; but, at maintained body weights below 88%, the correlation between weight and fat in LH rats was only +0.07. Variation in lean body mass then better accounted for differences in body weight. The implications of these observations for existing lipostatic theories of weight regulation are discussed.
对160只雄性大鼠进行了胴体分析，这些大鼠分别在外侧下丘脑（LH）损伤、假手术（对照）或腹内侧下丘脑（VMH）损伤后维持体重降低、正常或升高水平。提取的身体脂质（范围为对照平均值的26%至738%）与维持的体重水平高度相关（r = +0.95）（维持的体重范围为对照的67%至191%）。非脂肪固体（范围为对照的60%至123%）对体重变化均无显著贡献（r分别为+0.01和+0.06）。因此，脂肪约占LH、对照和VMH组动物体重总体变化的90%。然而，仅考虑LH组数据时，发现体脂与体重之间这种紧密的协方差出现了破裂。在体重维持在比正常水平低0 - 12%的LH大鼠中，脂肪量与体重显著相关；但是，在维持体重低于88%时，LH大鼠体重与脂肪之间的相关性仅为+0.07。此时，瘦体重的变化能更好地解释体重差异。本文讨论了这些观察结果对现有的体重调节脂肪稳态理论的影响。
