Thompson R G, Rodriguez A, Kowarski A, Blizzard R M
J Clin Invest. 1972 Dec;51(12):3193-9. doi: 10.1172/JCI107146.
A constant withdrawal pump was used to determine the integrated concentration of growth hormone (ICGH) which was used in conjunction with the metabolic clearance rate (MCR) of growth hormone (GH) to calculate the GH production rates (GHPR) in normal adults, acromegalics, and normal controls receiving prednisone. The mean ICGH for 22 premenopausal females on no medication was 3.0+/-1.6 ng/ml (sd) which is significantly lower (P < 0.005) than the mean of 6.6+/-2.9 for 10 women receiving oral contraceptives and significantly higher than the means of 1.5+/-0.75 for 5 postmenopausal females (P < 0.05) and 1.8+/-1.0 for 16 adult males (P < 0.01) which are comparable. The mean GHPR's in mg/24 hr per m(2) for the four groups are: normal females = 0.52+/-0.24 (sd), females receiving contraceptive pills = 1.65+/-0.58 (P < 0.005), postmenopausal females = 0.26+/-0.12 (P < 0.025), and adult males 0.35+/-0.23 (P < 0.025).Three untreated acromegalic patients had ICGH's of 59, 82, and 93 ng/ml and GHPR's ranging from 14.5 to 17.9 mg/24 hr. Prednisone in a dose of 20 mg t.i.d. for 8 days significantly decreased both the ICGH and GHPR. Alternate day prednisone (60 mg in a single q.o.d. dose) resulted in less consistent inhibition of GH release which may play a role in the more normal growth seen in children receiving q.o.d. prednisone.
使用恒速抽吸取样泵测定生长激素的整合浓度（ICGH），并结合生长激素（GH）的代谢清除率（MCR）来计算正常成年人、肢端肥大症患者以及接受泼尼松治疗的正常对照者的生长激素分泌率（GHPR）。22名未用药的绝经前女性的平均ICGH为3.0±1.6 ng/ml（标准差），显著低于10名服用口服避孕药女性的平均水平6.6±2.9（P<0.005），且显著高于5名绝经后女性的平均水平1.5±0.75（P<0.05）以及16名成年男性的平均水平1.8±1.0（P<0.01），后两者较为相近。四组的平均GHPR（每平方米每24小时的毫克数）分别为：正常女性=0.52±0.24（标准差），服用避孕药的女性=1.65±0.58（P<0.005），绝经后女性=0.26±0.12（P<0.025），成年男性=0.35±0.23（P<0.025）。三名未经治疗的肢端肥大症患者的ICGH分别为59、82和93 ng/ml，GHPR在14.5至17.9 mg/24小时之间。每日三次服用20 mg泼尼松，共8天，可显著降低ICGH和GHPR。隔日服用泼尼松（单次剂量60 mg）对GH释放的抑制作用不太稳定，这可能与隔日服用泼尼松的儿童生长更为正常有关。
