Benito P, Avila L, Corpas M S, Jiménez J A, Cacicedo L, Sánchez Franco F
Department of Internal Medicine, Reina Sofía Hospital, Cordoba, Spain.
J Endocrinol Invest. 1991 Apr;14(4):265-8. doi: 10.1007/BF03346809.
The aim of the present study was to ascertain whether sex differences exist in GH response to GHRH, and the influence that menstrual cycle have on this response. A GHRH test was performed on nine healthy men and ten women on days one and twelve of the menstrual cycle. Basal GH levels, (mean +/- SE) (7.98 +/- 3.09 ng/ml in women and 0.13 +/- 0.07 ng/ml in men, p less than 0.05) as well as maximal GH response (40.17 +/- 11.96 ng/ml in women and 9.63 +/- 2.32 ng/ml in males, p less than 0.01) were significantly higher in women than in men. In spite of a significant increase in estradiol levels during the menstrual cycle (75.88 +/- 2.48 pg/ml on day one and 198.40 +/- 28.65 pg/ml on day twelve, p less than 0.01) neither basal plasma GH levels, nor GH response to GHRH were significantly different. In conclusion, these results confirm that GH response to GHRH is higher in women than in men, and that this difference is not modified during the first phase of the menstrual cycle.
本研究的目的是确定生长激素（GH）对生长激素释放激素（GHRH）的反应是否存在性别差异，以及月经周期对此反应的影响。在月经周期的第1天和第12天，对9名健康男性和10名女性进行了GHRH测试。基础GH水平（平均值±标准误）（女性为7.98±3.09 ng/ml，男性为0.13±0.07 ng/ml，p<0.05）以及最大GH反应（女性为40.17±11.96 ng/ml，男性为9.63±2.32 ng/ml，p<0.01）女性均显著高于男性。尽管月经周期中雌二醇水平显著升高（第1天为75.88±2.48 pg/ml，第12天为198.40±28.65 pg/ml，p<0.01），但基础血浆GH水平和对GHRH的GH反应均无显著差异。总之，这些结果证实，女性对GHRH的GH反应高于男性，且在月经周期的第一阶段这种差异未被改变。
