西非的疟疾与红细胞葡萄糖-6-磷酸脱氢酶变体
Malaria and erythrocyte glucose-6-phosphate dehydrogenase variants in West Africa.
作者信息
Bienzle U, Guggenmoos-Holzmann I, Luzzatto L
出版信息
Am J Trop Med Hyg. 1979 Jul;28(4):619-21.
PMID:464185
Abstract
In a clinical study, 702 Nigerian children aged 1-6 years were examined for malaria. Comparison of morbidity rates and parasitemia of patients with different glucose-6-phosphate dehydrogenase (G6PD) status provided evidence that in heterozygous females the gene for G6PD deficiency (GdA-/GdB) confers an advantage against malaria.
摘要
在一项临床研究中，对702名1至6岁的尼日利亚儿童进行了疟疾检查。对不同葡萄糖-6-磷酸脱氢酶（G6PD）状态患者的发病率和寄生虫血症进行比较，结果表明，在杂合子女性中，G6PD缺乏基因（GdA-/GdB）赋予了抵抗疟疾的优势。
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