孕期及哺乳期早期兔乳腺中的脂肪酸生物合成
Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation.
作者信息
Strong C R, Dils R
出版信息
Biochem J. 1972 Aug;128(5):1303-9. doi: 10.1042/bj1281303.
Abstract
The pattern of fatty acids synthesized by mammary-gland explants from rabbits during pregnancy and early lactation has been studied. From day 12 to day 18 of pregnancy, long-chain (C(14:0)-C(18:1)) fatty acids were the major products. From day 18 to day 21 of pregnancy there was an increase of up to 12-fold in the rate of fatty acid synthesis per unit wet weight of tissue that was almost exclusively caused by the synthesis of octanoic fatty acid and decanoic fatty acid, which are characteristic of rabbit milk. These medium-chain fatty acids were mainly incorporated into triglycerides. From day 22 to day 27 of pregnancy there was little change in the rate of fatty acid synthesis and the proportions of fatty acids synthesized were essentially the same as those synthesized by the lactating gland, i.e. 80-90% octanoic acid plus decanoic acid. About 2-4 days before parturition a second lipogenic stimulus occurred, although the pattern of fatty acids synthesized did not change.
摘要
对兔乳腺外植体在怀孕期和泌乳早期合成脂肪酸的模式进行了研究。在怀孕的第12天到第18天，长链（C(14:0)-C(18:1)）脂肪酸是主要产物。在怀孕的第18天到第21天，每单位湿重组织的脂肪酸合成速率增加了高达12倍，这几乎完全是由辛酸和癸酸的合成引起的，而辛酸和癸酸是兔奶的特征成分。这些中链脂肪酸主要被掺入甘油三酯中。在怀孕的第22天到第27天，脂肪酸合成速率几乎没有变化，合成的脂肪酸比例与泌乳期乳腺合成的基本相同，即80-90%为辛酸加癸酸。在分娩前约2-4天，出现了第二次生脂刺激，尽管合成的脂肪酸模式没有改变。
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