Martyn P, Hansen I A
Biochem J. 1980 Jul 15;190(1):171-5. doi: 10.1042/bj1900171.
The rate of fatty acid synthesis from [6-14C]glucose in mammary tissue remained low until parturition at 22 days of gestation and increased 10-fold at 1 day post partum. Administration of progesterone on days 20 and 21 or removal of pups at parturition abolished this increase. In the latter case, administration of prolactin, corticosterone or oxytocin had no stimulatory effect; tissue from suckled glands in which the ducts had been ligated at parturition also showed no increased rate in 24 h. Foetoplacentectomy on day 18 did not stimulate fatty acid synthesis but subsequent suckling by foster pups did. Whereas lactose synthesis is initiated by withdrawal of progesterone from the circulation, a further stimulus related to removal of milk by suckling is required to initiate fatty acid synthesis.
在妊娠22天分娩前，乳腺组织中由[6-¹⁴C]葡萄糖合成脂肪酸的速率一直很低，而在产后1天增加了10倍。在妊娠第20天和第21天给予孕酮或在分娩时取出幼崽可消除这种增加。在后一种情况下，给予催乳素、皮质酮或催产素没有刺激作用；分娩时结扎导管的哺乳乳腺组织在24小时内也没有显示出合成速率增加。在第18天进行胎儿胎盘切除术不会刺激脂肪酸合成，但随后由代乳幼崽哺乳则会刺激。虽然乳糖合成是由循环中孕酮的撤离启动的，但启动脂肪酸合成还需要与通过哺乳清除乳汁相关的进一步刺激。
