Gray R G, Poppo M J, Gottlieb N L
Ann Intern Med. 1979 Jul;91(1):37-40. doi: 10.7326/0003-4819-91-1-37.
We identified bilateral carpal tunnel syndrome in 19 of 43 living persons of a nonconsanguineous family. No single common etiologic feature was seen. Sixty-three percent of the afflicted kindred had symptomatic digital flexor tenosynovitis. Noninflammatory thickening of the flexor retinaculum or tendon sheaths, or both, was the commonest surgical finding. The 44% prevalence, early age of onset, and equal sex ratio differ from idiopathic carpal tunnel syndrome. Family pedigree suggests an inheritable disorder transmitted by an autosomal dominant gene with a high degree of penetrance.
我们在一个非近亲家庭的43名在世成员中，发现了19例双侧腕管综合征患者。未发现单一的共同病因特征。63%的患病亲属患有症状性指屈肌腱腱鞘炎。屈肌支持带或腱鞘或两者的非炎性增厚是最常见的手术发现。44%的患病率、发病年龄早以及性别比例相同，这些与特发性腕管综合征不同。家系图谱表明这是一种由常染色体显性基因传递、具有高度外显率的遗传性疾病。
