Simkin P A, Hoover P L, Paxson C S, Wilson W F
Ann Intern Med. 1979 Jul;91(1):44-7. doi: 10.7326/0003-4819-91-1-44.
Uric acid excretion can be measured in milligrams of urinary uric acid per decilitre of glomerular filtrate by obtaining the product of urinary uric acid and serum creatinine concentrations and dividing by the urine creatinine (all concentrations in mg/dL). In 29 normal adult men, the excretion rate in spot, midmorning samples was 0.4 +/- 0.1 (SD) mg of uric acid per decilitre of glomerular filtrate. Eight of 36 untreated gouty men excreted acid at a rate more than three standard deviations above normal. Excretion of uric acid is conveniently and physiologically assessed by this simple method.
尿酸排泄量可以通过获取尿酸和血清肌酐浓度的乘积并除以尿肌酐（所有浓度单位均为mg/dL）来计算，以每分升肾小球滤过液中尿酸的毫克数来衡量。在29名正常成年男性中，上午中段随机尿样的排泄率为每分升肾小球滤过液0.4±0.1（标准差）毫克尿酸。36名未经治疗的痛风男性中有8人的尿酸排泄率高于正常水平三个标准差以上。通过这种简单的方法可以方便且符合生理地评估尿酸排泄情况。
