Little W A, Thomson L A, Bowen W H
Antimicrob Agents Chemother. 1979 Mar;15(3):440-3. doi: 10.1128/AAC.15.3.440.
A total of 82 strains of Streptococcus mutans representing serotypes a through g were tested for susceptibility to erythromycin, penicillin, methicillin, lincomycin, tetracycline, vancomycin, gentamicin, streptomycin, neomycin, kanamycin, bacitracin, and polymyxin B. Strains included stock cultures and isolates from human and animal dental plaque. Minimal inhibitory concentrations were determined by a broth-microdilution procedure. The major differences in antibiotic susceptibility observed among the serotypes resulted with antibiotics which act on the cell surface. Bacitracin was most active against serotype a strains and polymyxin B against serotype b strains. Serotypes a, d, and g were less susceptible than the other serotypes to methicillin.
对总共82株代表血清型a至g的变形链球菌菌株进行了红霉素、青霉素、甲氧西林、林可霉素、四环素、万古霉素、庆大霉素、链霉素、新霉素、卡那霉素、杆菌肽和多粘菌素B的药敏试验。菌株包括标准菌株以及从人和动物牙菌斑中分离出的菌株。最低抑菌浓度通过肉汤微量稀释法测定。在血清型之间观察到的抗生素敏感性的主要差异与作用于细胞表面的抗生素有关。杆菌肽对血清型a菌株最有效,多粘菌素B对血清型b菌株最有效。血清型a、d和g比其他血清型对甲氧西林更不敏感。