Weld H G, Sandham H J
Antimicrob Agents Chemother. 1976 Aug;10(2):200-4. doi: 10.1128/AAC.10.2.200.
Plaque samples were obtained from 13 children receiving long-term therapy with benzathine penicillin for the prevention of rheumatic fever recurrences, 31 children receiving oral sulfadiazine for the same purpose, and 29 untreated siblings. The therapies were found to have no effect upon the proportions of Streptococcus mutans or lactobacilli in dental plaque, upon the percentage of children harboring the organisms, nor upon the susceptibility of the organisms to penicillin and sulfadiazine. Of the S. mutans strains tested, 97% had a minimal inhibitory concentration of penicillin G of less than 48 ng/ml and, of the lactobacillus strains tested, 96.8% had a minimal inhibitory concentration of less than 1,600 ng/ml. All strains of both organisms were profoundly resistant to sulfadiazine.
从13名接受苄星青霉素长期治疗以预防风湿热复发的儿童、31名接受口服磺胺嘧啶用于相同目的的儿童以及29名未接受治疗的同胞兄弟姐妹中获取菌斑样本。结果发现，这些治疗方法对牙菌斑中变形链球菌或乳酸杆菌的比例、携带这些微生物的儿童百分比，以及这些微生物对青霉素和磺胺嘧啶的敏感性均无影响。在所测试的变形链球菌菌株中，97%对青霉素G的最低抑菌浓度低于48纳克/毫升，在所测试的乳酸杆菌菌株中，96.8%对青霉素G的最低抑菌浓度低于1600纳克/毫升。这两种微生物的所有菌株对磺胺嘧啶均具有高度耐药性。
