内酰胺链霉菌的孢子形成以及丝氨酸蛋白酶和头霉素C的产生。
Sporulation and the production of serine protease and cephamycin C by Streptomyces lactamdurans.
作者信息
Ginther C L
出版信息
Antimicrob Agents Chemother. 1979 Apr;15(4):522-6. doi: 10.1128/AAC.15.4.522.
Abstract
Streptomyces lactamdurans, producer of the antibiotic cephamycin C, excretes at least two proteases. Physiological studies indicate that antibiotic synthesis and serine protease formation are coordinately regulated. Both are produced only after culture growth ends, and they appear with essentially identical kinetics. In addition, strains which produce superior levels of cephamycin C form equally superior levels of the serine protease. Genetic evidence reveals that the syntheses of the antibiotic and serine proteases are associated with sporulation. Mutants which fail to produce aerial hyphae (bald mutants) also fail to synthesize the antibiotic and serine proteases.
摘要
抗生素头孢霉素C的产生菌耐乳内酰胺链霉菌能分泌至少两种蛋白酶。生理学研究表明，抗生素合成和丝氨酸蛋白酶的形成受到协同调控。两者都仅在培养生长结束后产生，且它们的出现具有基本相同的动力学。此外，产生高水平头孢霉素C的菌株也能形成同样高水平的丝氨酸蛋白酶。遗传学证据表明，抗生素和丝氨酸蛋白酶的合成与孢子形成有关。不能产生气生菌丝的突变体（光秃突变体）也不能合成抗生素和丝氨酸蛋白酶。
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