Jansson E, Hannuksela M, Eklund H, Halme H, Tuuri S
J Clin Pathol. 1972 Oct;25(10):837-42. doi: 10.1136/jcp.25.10.837.
Using a modified cell-free culture medium, a mycoplasma was isolated from sarcoid lymph nodes in two cases and from sarcoid skin lesions in four out of seven cases of chronic sarcoidosis. Growth inhibition tests showed that the isolates were related to Mycoplasma orale type 1. By the indirect haemagglutination method, 244 cases of definite or probable sarcoidosis, 160 patients with other diseases, and 355 blood donors were tested for antibodies against an isolated mycoplasma (strain 215-M). Titres [unk] 16 were found in 14% of the patients with sarcoidosis and in 8% of the patients with other diseases but only in 0.6% of the blood donors. The proportion of patients with high antibody titres among those with sarcoidosis and erythema nodosum was smaller (8%) than among those with other forms of sarcoidosis (17%). The role of the mycoplasmas isolated from sarcoid tissues remains obscure, but it is possible that these organisms are only an expression of altered immunity in sarcoidosis.
使用改良的无细胞培养基，从2例结节病患者的淋巴结以及7例慢性结节病患者中4例的皮肤病变处分离出支原体。生长抑制试验表明，分离出的菌株与1型口腔支原体有关。采用间接血凝法，对244例确诊或疑似结节病患者、160例其他疾病患者以及355名献血者进行了针对分离出的支原体（菌株215-M）的抗体检测。在结节病患者中，14%的患者抗体滴度≥16；在其他疾病患者中，这一比例为8%；而在献血者中仅为0.6%。结节病合并结节性红斑患者中高抗体滴度患者的比例（8%）低于其他形式结节病患者（17%）。从结节病组织中分离出的支原体的作用尚不清楚，但这些微生物有可能只是结节病中免疫改变的一种表现。
