Roe B B, Hutchinson J C, Fishman N H, Ullyot D J, Smith D L
J Thorac Cardiovasc Surg. 1977 Mar;73(3):366-74.
A total of 204 patients, ages 3 months to 84 years, underwent open-heart surgery with the aid of cardiopulmonary bypass with moderate hypothermia. For protection of the myocardium, cardioplegia was induced by washing out the coronary arteries with an iced, buffered, isoosmolar, potassium-based infusate. After aortic cross-clamping, the aortic root or individual coronary arteries were perfused with 500 to 2,000 c.c. of an aqueous solution (at zero to 4 degrees C.) containing 20 mEq. of potassium. Periods of ischemic arrest as long as 208 minutes have been well tolerated, with only two of the eleven hospital deaths considered heart related. Defibrillation occurred spontaneously in 41 per cent and after one shock in 47 per cent of patient, without apparent correlation between duration of ischemia and restoration of effective rhythm.
共有204例年龄在3个月至84岁之间的患者，在中度低温体外循环辅助下接受了心脏直视手术。为保护心肌，通过用冰的、缓冲的、等渗的、含钾灌注液冲洗冠状动脉来诱导心脏停搏。主动脉交叉钳夹后，用500至2000毫升含有20毫当量钾的水溶液（0至4摄氏度）灌注主动脉根部或个别冠状动脉。长达208分钟的缺血性停搏期耐受性良好，11例医院死亡病例中只有2例被认为与心脏有关。41%的患者自发发生除颤，47%的患者在一次电击后发生除颤，缺血持续时间与有效心律恢复之间无明显相关性。
