Rosenbloom A L, Tiwary C M
Arch Dis Child. 1972 Dec;47(256):924-6. doi: 10.1136/adc.47.256.924.
Two children with intermittent hypoglycaemia, associated with vomiting and occurring in the morning after breakfast, were unresponsive to the hyperglycaemic effect of glucagon in the fasting state. Fed-state glucagon response was normal. Urinary catecholamine excretion rate tripled during 18 to 24 hours of fasting. Treatment with ephedrine sulphate 2·5 mg/kg body weight per day divided into 6-hourly doses, much improved fasting tolerance and restored the glycaemic response to glucagon in the fasting state. The ephedrine was without side effects and has completely eradicated hypoglycaemic episodes in one of the children during 22 months use.
两名患有间歇性低血糖症的儿童，伴有呕吐，且在早餐后的早晨发作，在空腹状态下对胰高血糖素的升血糖作用无反应。进食状态下的胰高血糖素反应正常。禁食18至24小时期间，尿儿茶酚胺排泄率增加了两倍。每天给予硫酸麻黄碱2.5毫克/千克体重，分6小时剂量服用，显著改善了空腹耐受性，并恢复了空腹状态下对胰高血糖素的血糖反应。麻黄碱无副作用，在一名儿童使用22个月期间已完全消除了低血糖发作。
