• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Metabolism of 3,4-dihydroxyphenylalanine (L-dopa) in human subjects.

作者信息

Goodall M, Alton H

出版信息

Biochem Pharmacol. 1972 Sep 1;21(17):2401-8. doi: 10.1016/0006-2952(72)90392-9.

DOI:10.1016/0006-2952(72)90392-9
PMID:4647074
Abstract
摘要

相似文献

1
Metabolism of 3,4-dihydroxyphenylalanine (L-dopa) in human subjects.人类受试者中3,4-二羟基苯丙氨酸(左旋多巴)的代谢
Biochem Pharmacol. 1972 Sep 1;21(17):2401-8. doi: 10.1016/0006-2952(72)90392-9.
2
Studies on the metabolism and excretion of L-3,4-dihydroxyphenylalanine (L-DOPA) in human beings by gas chromatography.采用气相色谱法对人体中L-3,4-二羟基苯丙氨酸(L-DOPA)的代谢和排泄进行的研究。
Chem Pharm Bull (Tokyo). 1972 Apr;20(4):759-64. doi: 10.1248/cpb.20.759.
3
The excretion of L-dopa metabolites at different hours of the day.
Curr Ther Res Clin Exp. 1972 Nov;14(11):749-57.
4
Metabolism of L-dihydroxyphenylalanine by patients with Parkinson's disease.
Mayo Clin Proc. 1970 Sep;45(9):645-56.
5
Metabolism of L-3,4-dihydroxyphenylalanine-2,5,6-3H and 3,4-dihydroxyphenylethylamine-2-14C in a patient with neuroblastoma.一名神经母细胞瘤患者体内L-3,4-二羟基苯丙氨酸-2,5,6-³H和3,4-二羟基苯乙胺-2-¹⁴C的代谢
J Clin Endocrinol Metab. 1971 Feb;32(2):241-53. doi: 10.1210/jcem-32-2-241.
6
Dose-related alterations in metabolism of levodopa: possible mechanism for hypotensive effect.
J Clin Pharmacol. 1974 Aug-Sep;14(8):448-54. doi: 10.1002/j.1552-4604.1974.tb02327.x.
7
[Clinical, electroencephalographic and biochemical aspects of the 1-dopa effect].[左旋多巴效应的临床、脑电图及生化方面]
Arzneimittelforschung. 1966 Feb;16(2):265-7.
8
Urinary excreion of DOPA and metabolites by patients with melanoma.
Cancer. 1970 Jul;26(1):146-9. doi: 10.1002/1097-0142(197007)26:1<146::aid-cncr2820260119>3.0.co;2-4.
9
[Qualitative analysis of the main urinary metabolites of dopamine, epinephrine and norepinephrine by gas chromatography].[气相色谱法对多巴胺、肾上腺素和去甲肾上腺素主要尿代谢物的定性分析]
Pathol Biol (Paris). 1971 Aug-Sep;19(15):719-25.
10
Imipramine-mediated effects on levodopa metabolism in man.丙咪嗪对人体左旋多巴代谢的影响。
Biochem Pharmacol. 1974 May 15;23(10):1503-7. doi: 10.1016/0006-2952(74)90387-6.

引用本文的文献

1
Metabolite profiling of foslevodopa/foscarbidopa in plasma of healthy human participants by LC-HRMS indicates no major differences compared to administration of levodopa/carbidopa intestinal gel.采用 LC-HRMS 对健康人体参与者血浆中的 foslevodopa/foscarbidopa 进行代谢物分析,结果表明与给予左旋多巴/卡比多巴肠凝胶相比无明显差异。
Pharmacol Res Perspect. 2024 Apr;12(2):e1190. doi: 10.1002/prp2.1190.
2
Evaluation of Intraperitoneal [F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity.腹腔内[F]-FDOPA 给药用于小鼠微 PET 成像的评价及亚慢性氯胺酮给药对多巴胺合成能力影响的评估。
Mol Imaging. 2022 Oct 28;2022:4419221. doi: 10.1155/2022/4419221. eCollection 2022.
3
Determination of levodopa by chromatography-based methods in biological samples: a review.基于色谱法的生物样本中左旋多巴测定方法的研究进展。
Anal Sci. 2022 Aug;38(8):1009-1017. doi: 10.1007/s44211-022-00132-4. Epub 2022 Jun 17.
4
Toward the understanding of the metabolism of levodopa I. DFT investigation of the equilibrium geometries, acid-base properties and levodopa-water complexes.迈向左旋多巴代谢的理解 I. 左旋多巴平衡几何结构、酸碱性质及左旋多巴-水络合物的密度泛函理论研究
Int J Mol Sci. 2012;13(4):4321-4339. doi: 10.3390/ijms13044321. Epub 2012 Apr 2.
5
Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease.用于治疗帕金森病的药物的临床药代动力学和药效学特性。
Clin Pharmacokinet. 2002;41(4):261-309. doi: 10.2165/00003088-200241040-00003.
6
Urinary catecholamine metabolites (vanylmandelic and homovanillic acids) in the rat after subchronic treatment with sodium nitrate or nitrite.用硝酸钠或亚硝酸钠对大鼠进行亚慢性治疗后其尿中儿茶酚胺代谢产物(香草扁桃酸和高香草酸)的情况。
Experientia. 1982 Apr 15;38(4):486-8. doi: 10.1007/BF01952653.
7
Studies on the sulphation of 3,4-dihydroxyphenylethylamine (dopamine) and related compounds by rat tissues.大鼠组织对3,4 -二羟基苯乙胺(多巴胺)及相关化合物的硫酸化作用研究。
Biochem J. 1973 Sep;135(1):109-14. doi: 10.1042/bj1350109.
8
Intestinal decarboxylation of L-Dopa in relation to dose requirement in Parkinson's disease.
Naunyn Schmiedebergs Arch Pharmacol. 1973;280(4):429-39. doi: 10.1007/BF00506633.
9
Clinical pharmacokinetics of anti-parkinsonian drugs.抗帕金森病药物的临床药代动力学
Clin Pharmacokinet. 1987 Sep;13(3):141-78. doi: 10.2165/00003088-198713030-00002.