母羊注射茶碱或速尿后出现的低镁血症：肾脏与肾外效应
Hypomagnesaemia following theophylline or furosemide injection in ewes: renal versus extrarenal effect.
作者信息
Larvor P, Rayssiguier Y
出版信息
J Physiol. 1972 Dec;227(2):365-75. doi: 10.1113/jphysiol.1972.sp010037.
Abstract
- Intravenous theophylline infusion (30 mg/kg body weight during 90 min) induces in normal ewes a magnesuria associated with hypomagnesaemia. Intravenous furosemide infusion (1 mg/kg body weight during 90 min) induces in the same animals a similar magnesuria with only a slight hypomagnesaemia.2. In magnesium deficient ewes, theophylline induces a hypomagnesaemia, without a significant rise in magnesuria.3. Theophylline infusion, with simultaneous reinjection of the excess magnesium excreted in urine, induces a significant hypomagnesaemia.4. Thyroidectomy does not inhibit the effect of theophylline on magnesaemia.5. It is concluded that the effect of theophylline on magnesaemia is mainly of extrarenal origin, while the effect of furosemide is only renal. The effect of theophylline is not mediated through calcitonin secretion.
摘要
静脉输注氨茶碱（90分钟内30毫克/千克体重）可在正常母羊中诱发与低镁血症相关的镁尿症。静脉输注呋塞米（90分钟内1毫克/千克体重）在相同动物中诱发类似的镁尿症，仅伴有轻微的低镁血症。
在缺镁的母羊中，氨茶碱诱发低镁血症，但镁尿症无显著增加。
输注氨茶碱的同时重新注射尿液中排泄的过量镁，可诱发显著的低镁血症。
甲状腺切除术不抑制氨茶碱对镁血症的影响。
得出的结论是，氨茶碱对镁血症的影响主要源于肾外，而呋塞米的影响仅源于肾脏。氨茶碱的作用不是通过降钙素分泌介导的。
相似文献
1
Hypomagnesaemia following theophylline or furosemide injection in ewes: renal versus extrarenal effect.母羊注射茶碱或速尿后出现的低镁血症：肾脏与肾外效应
J Physiol. 1972 Dec;227(2):365-75. doi: 10.1113/jphysiol.1972.sp010037.
2
Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive heart failure: pathophysiological correlates and prognostic evaluation.使用速尿（呋塞米）治疗的充血性心力衰竭患者的血清镁异常：病理生理相关性及预后评估
Heart. 2003 Apr;89(4):411-6. doi: 10.1136/heart.89.4.411.
3
Hypomagnesemia resulting from adrenaline infusion in ewes: its relation to lipolysis.肾上腺素输注导致母羊低镁血症：其与脂肪分解的关系。
Horm Metab Res. 1977 Jul;9(4):309-14. doi: 10.1055/s-0028-1093519.
4
Acute treatment of hypercalcemia with furosemide.速尿对高钙血症的急性治疗作用。
N Engl J Med. 1970 Oct 15;283(16):836-40. doi: 10.1056/NEJM197010152831603.
5
Effect of intravenous furosemide on serum theophylline concentration.静脉注射呋塞米对血清茶碱浓度的影响。
Am J Hosp Pharm. 1981 Sep;38(9):1345-7.
6
Evidence for renal magnesium secretion during magnesium infusions in the dog.犬输注镁期间肾脏分泌镁的证据。
Am J Physiol. 1971 Jan;220(1):33-7. doi: 10.1152/ajplegacy.1971.220.1.33.
7
Thyroid C cells in experimental hyper- and hypomagnesaemia.
Virchows Arch B Cell Pathol. 1970;5(2):173-86. doi: 10.1007/BF02893560.
8
A randomized trial of saline hydration to prevent contrast nephropathy in chronic renal failure patients.一项关于生理盐水水化预防慢性肾衰竭患者造影剂肾病的随机试验。
Nephrol Dial Transplant. 2006 Aug;21(8):2120-6. doi: 10.1093/ndt/gfl133. Epub 2006 Apr 12.
9
The comparison of the diuretic and natriuretic efficacy of continuous and bolus intravenous furosemide in patients with chronic kidney disease.慢性肾脏病患者持续静脉输注与大剂量静脉推注呋塞米的利尿和利钠效果比较
Nephrology (Carlton). 2008 Jun;13(3):247-50. doi: 10.1111/j.1440-1797.2007.00889.x.
10
[Effect of furosemide on water and sodium excretion in apparently normal infants].[速尿对貌似正常婴儿水钠排泄的影响]
Bol Med Hosp Infant Mex. 1976 May-Jun;33(3):693-8.
引用本文的文献
1
Further studies on theophylline-induced hypocalcaemia in sheep.绵羊中茶碱诱导低钙血症的进一步研究。
Acta Vet Scand. 1975;16(1):39-50. doi: 10.1186/BF03546694.
本文引用的文献
1
A STUDY OF THE ACTION OF AMMONIUM CHLORID AND ORGANIC MERCURY COMPOUNDS.氯化铵与有机汞化合物作用的研究
J Clin Invest. 1926 Oct;3(1):149-202. doi: 10.1172/JCI100072.
2
Clinical studies of magnesium metabolism.镁代谢的临床研究。
Med Clin North Am. 1952 Jul;21:1157-71.
3
Influence of the renal excretion of sodium chloride upon the renal excretion of magnesium and other ions by human subjects.人体受试者中氯化钠的肾排泄对镁及其他离子肾排泄的影响。
J Clin Endocrinol Metab. 1959 Oct;19:1192-211. doi: 10.1210/jcem-19-10-1192.
4
5
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
J Biol Chem. 1962 Apr;237:1244-50.
6
The clinical expression of magnesium deficiency.
JAMA. 1960 Sep 3;174:77-8. doi: 10.1001/jama.1960.63030010028022b.
7
Studies of the renal excretion of magnesium in man.人体镁的肾脏排泄研究。
J Clin Invest. 1959 Oct;38(10 Pt 1-2):1733-45. doi: 10.1172/JCI103952.
8
The effect of ammonium chloride and sodium bicarbonate on the urinary excretion of magnesium, calcium, and phosphate.氯化铵和碳酸氢钠对镁、钙和磷酸盐尿排泄的影响。
Am Heart J. 1961 Aug;62:206-10. doi: 10.1016/0002-8703(61)90319-2.
9
The determination of magnesium in biological materials by atomic absorption spectrophotometry.用原子吸收分光光度法测定生物材料中的镁
Biochem J. 1961 Jul;80(1):99-106. doi: 10.1042/bj0800099.
10
[Research on the effect of various diuretics on renal magnesium and calcium excretion].[不同利尿剂对肾脏镁和钙排泄影响的研究]
Klin Wochenschr. 1960 Nov 15;38:1168. doi: 10.1007/BF01492890.
Zotero 插件