Caputi A P, Rossi F, Lampa E, Imperatore A, Visone C, Marmo E
Arch Sci Med (Torino). 1979 Jan-Mar;136(1):1-15.
It was shown experimentally that mexilithene possesses anti-arrhythmic activity with slight depression of sino-carotid baroreceptorial and glomo-carotid and gangliar chemoreceptorial activity and catecholamine uptake. Hypotensive and bradycardizing effects were only noted when high per kg doses were used. The drug did not display vascular alpha- and beta-adrenolytic, anti-muscarinic and anti-histaminic activity.
实验表明，美西律具有抗心律失常活性，对窦-颈动脉压力感受器、球-颈动脉和神经节化学感受器的活性以及儿茶酚胺摄取仅有轻微抑制作用。仅在使用每千克高剂量时才观察到降压和减慢心率的作用。该药物未表现出血管α和β肾上腺素能阻断、抗毒蕈碱和抗组胺活性。
